The drive to address agricultural animal welfare increases as the demand for food of animal origins correspondingly grows. A major emerging challenge is the continuous need to meet animal protein demands while simultaneously protecting animal welfare and developing broadly sustainable production systems. Large-scale, intensive systems predominate production animal agriculture in the United States. These systems continue to generate concerns and public debates about the treatment of farm animals, the conceptions of sustainability, the social responsibility of food production systems, and the safety and quality of food. This report, in comparison to the 1997 CAST Task Force Report, shows a growing emphasis on animal welfare regulations. The priorities, state of the science, challenges, and approaches to addressing the topic have also evolved considerably. Increased collaboration has occurred between scientists and philosophers to address agricultural bioethics in an effort to facilitate conflict resolution.