Maize engineered to silence deadly toxins in poisonous mold

It’s a silent killer lurking in common foods. A carcinogenic toxin made by mould kills thousands around the world and forces millions of tonnes of infected crops to be discarded each year.  But a new approach could turn off production of the poison even when mould does grow on the crops.Maize plants have been genetically modified to deliver strands of so-called interfering RNA that silence toxin-producing genes in a fungus that commonly grows on the crop.This GM corn can police the Aspergillus fungus on its own cobs and stop it producing poisonous aflatoxin that causes liver disease and cancer. The maize was engineered to express the gene-silencing RNA molecules by Monica Schmidt at the University of Arizona and colleagues. Her team then exposed this GM maize, along with a non-GM variety, to the fungal spores as they grew for a month. The fungus grew on both, but while high levels of toxin were found on the non-GM maize, the toxins were undetectable on the GM plants.