Beth Macy’s book about the opioid crisis in southwest Virginia contains plenty of tragedy — families decimated, lives lost or ruined, proud communities brought to their knees. The biggest tragedy of all, of course, is that the story could have turned out differently.In the earliest days of the crisis, prophetic voices in rural Virginia sounded the alarm. The pharmaceutical manufacturer whose criminal marketing practices helped launch the epidemic didn’t listen. Nor did federal regulators, until the genie was out of the bottle.Macy traces the epidemic from the coalfields of Appalachia to the affluent suburbs and small towns of the Shenandoah Valley. Her role as a working journalist based in the region gave her access to the people who know the story — addicts and their families, dealers, law enforcement, medical professionals, and community activists. Her skill as a reporter and writer combine to give the reader a direct connection to the crisis and its human cost.